The divine and unusual comedian Maria Bamford has a brilliant new series, “Lady Dynamite,” premiering Friday on Netflix; as is often the case with comedians who front sitcoms, it has something to do with her actual life. But that is the only case here that is often the case.

Created by Mitchell Hurwitz and Pam Brady, it is cheerful, dark, surreal, profane, aspirational, meta-fictional and packed with people playing versions of themselves or other people entirely (or playing versions of themselves playing other people entirely); it plays with visual and verbal puns, with moods and acting styles and moves around in time and dimension. And while these are elements of many modern comedies – it owes something to “It’s Garry Shandling’s Show,” “Curb Your Enthusiasm,” “30 Rock,” “The Sarah Silverman Program,” Hurwitz’s “Arrested Development” and the cracked spirit of Adult Swim – I have never seen them assembled in quite this way, or with quite so much gusto.